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immune checkpoint inhibitors combined with ferroptosis inducers, anti-PD-1 combined with ACSL4 agonists (such as RSL3), upregulate ACSL4 through the STAT1-IRF1 pathway, making tumor cells more sensitive to T cell-mediated ferroptosis (219)
Its essential to distinguish cancer prevention from cancer treatment
Recent estimates indicate that by 2050, the number of Americans with diabetes will have more than doubled, potentially affecting up to 33% of the adult population [3]
PMCID: PMC11890406
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